Name of the institute: INSERM U1065, Mediterranean Center for Molecular Medicine (C3M).
Name of the team: Metabolism, Cancer and Immune response
Name of the leader: JE RICCI, PhD Location: Nice, France.
Abstract of the project: We recently established that reducing the dietary intake of mice that develop B lymphomas by 25% a week was sufficient to reduce Mcl-1 expression and sensitize those mice to the targeted chemotherapy (Meynet et al Blood 2013, Meynet et al Trends Mol Med 2015). Using cutting edge technologies the PhD student will comprehensively detect the global cellular changes induced by specific diets in RNA, protein, cytokine and immune response. The project will be conducted in cell lines, murine and human primary cells as well as in vivo.