Institution: AMC (Academic Medical Center), Amsterdam
Team: Immuno-hematology group AMC, PI Eric Eldering.
Objectives: Understand and be able to influence metabolic changes induced by malignant cells that subvert T cell function.
Summary: Malignant cells alter the metabolic state and function of surrounding normal T cells. The candidate will investigate this in various B cell malignancies (FL, DLBCL, MM). Healthy donor T cells and patient T cells will be compared for metabolic parameters and in immune function, using cutting edge techniques and co-culture assays (Sea-horse metabolic analyser, metabolomics, candidate gene and drug screens)