Name of the institute: INSERM U1065, Mediterranean Center for Molecular Medicine (C3M).
Name of the team: Metabolism, Cancer and Immune response
Name of the leader: JE RICCI, PhD.
Location: Nice, France.
Abstract of the project: Diffuse large B-cell lymphoma (DLBCL) are very common and aggressive tumors with exacerbated metabolism. Despite the breakthrough treatments with anti-CD20 immunotherapy (Rituximab, R), associated with the conventional treatment CHOP (referred as R-CHOP), 40% of patients with DLBCL are ultimately in treatment failure. Interestingly, 80% of DLBCL do not express asparagine synthase (ASNs) that catalyzes the conversion of glutamine and aspartate into asparagine, a nonessential amino acid that participates in the synthesis of DNA and protein synthesis. Therefore, the PhD student, will analyze if L-Asparaginase (a drug that depletes Asn from the circulation) could be proposed as a complementary treatment to R-CHOP refractory patients. The project will be conducted in cell lines, murine and human primary cells as well as in vivo.
As part of our MSCA-ESR training on complementary skills we got to leave the wet lab to explore what happens on the other side of the bench and to learn what it means to be a scientific editor. This is our story.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 766214.
Bellvitge Biomedical
Research Institute (IDIBELL)
Hospital Duran i Reynals, 3a planta
Gran Via de l’Hospitalet, 199
08908 L’Hospitalet del Llobregat
Barcelona, Spain
