Institute: IDIBELL (Bellvitge Biomedical Research Institute). Barcelona, Spain
Team: Cell Death Regulation Group. PI Cristina Muñoz-Pinedo
Project: Anti-metabolic drugs promote of tumor cells, but they also induce effects on the tumor stroma and the immune system. The candidate will characterize cell-cell effects of a group of proteins secreted by tumor cells that may play a role in cancer response to anti-metabolic drugs. Experiments will include in vitro analysis of responses of different tumor microenvironment populations to experimental starvation, and in vivo effects of selected proteins during lung cancer and sarcoma development and treatment with anti-metabolites.