Name of partner: Evotec , Toulouse, France.
Name of leader: Nathalie Alet
Objectives: to identify metabolic genes that are modulated or mutated in acute myeloid leukemia patient samples. Set up in vivo model(s) suitable for validation of their interest.
Expected Results: We will model a metabolic gene profile in acute myeloid leukemia and link this gene profile to patient outcome according to the treatment received. Then drugs/compounds potentially modulating the metabolic profile in a beneficial way may be tested in vivo.